With a career that spans continents, Prof. Dedee Murrell stands out as a global leader in dermatology and a passionate advocate for women in medicine. In this episode, we sit down together to explore her inspiring journey—from her early years in the UK and medical training in the USA to pioneering therapies for some of dermatology’s rarest and underserved conditions in Australia. We also reflect on her recent MDS Lifetime Achievement Award and discuss the value of mentorship, strategies for advancing a career in dermatology and academic medicine, and how to stay at the cutting edge of medical innovation.
The IMPACT-PLuS long-term follow-up trial found that children who underwent peanut oral immunotherapy in the earlier IMPACT trial maintained significant changes in their allergen-specific IgE and IgG4 profiles, which could have positive implications for long-term allergy management.
The FDA has approved a 1 mg epinephrine nasal spray for treating type I allergic reactions, including anaphylaxis, in children over 4 years old, weighing between 15 and 30 kg. This nasal spray offers a needle-free alternative to traditional epinephrine injections, which may be avoided due to fear, especially among children.
Epinephrine is the first-line treatment for severe allergic reactions, including anaphylaxis, where prompt intervention is crucial. Epinephrine sublingual film, a novel prodrug of epinephrine, is being developed to treat Type 1 allergic reactions, such as anaphylaxis. In the OASIS study, epinephrine sublingual film demonstrated equal or superior pharmacokinetics compared to intramuscular epinephrine in adult patients with oral allergy syndrome. The film led to rapid symptom resolution, with a median recovery time of 12 minutes. Additionally, stability tests showed that the film remained effective under extreme temperatures and real-world conditions, ensuring its reliability as an emergency treatment for anaphylaxis.
Education, Conference Coverage and Articles
With a career that spans continents, Prof. Dedee Murrell stands out as a global leader in dermatology and a passionate advocate for women in medicine. In this episode, we sit down together to explore her inspiring journey—from her early years in the UK and medical training in the USA to pioneering therapies for some of dermatology’s rarest and underserved conditions in Australia. We also reflect on her recent MDS Lifetime Achievement Award and discuss the value of mentorship, strategies for advancing a career in dermatology and academic medicine, and how to stay at the cutting edge of medical innovation.
From advances in targeted therapies to the integration of AI and steps towards precision medicine, 2024 brought many exciting developments in the field. With 2025 now unfolding, many of these are likely to continue gaining momentum and potentially redefine patient care. In ...
Rheumatoid arthritis (RA) is one of the most challenging autoimmune diseases. Early, targeted and effective therapy is crucial for achieving remission and preventing long-term joint destruction. Over the past two decades, tumour necrosis factor (TNF) inhibitors (TNFi) have been the ...
The use of immune checkpoint inhibitors (ICIs) in treating cancer has greatly improved survival outcomes, particularly in patients with advanced disease for whom successful treatment options have previously been limited. For example, in patients with metastatic melanoma, the median survival ...
Watch leading experts discuss updates in the treatment of systemic lupus erythematosus (SLE), lupus nephritis (LN) and Sjögren’s disease, based on data presented at EULAR 2024.
Watch Drs Ronald Vender, Richard Warren and Xenofon Baraliakos discuss UCB’s contributions to the treatment of immunological disease.
Share your knowledge, influence clinical practices and enhance patient care in Immunology today!
Hypermobility spectrum disorders (HSDs) refer to a group of conditions characterized by an increased range of motion in joints beyond the normal limits, often due to connective tissue laxity. More stringent criteria are applied in the diagnosis of hypermobile Ehlers–...
Recent advancements made in understanding the pathology of inflammatory skin conditions have enabled JAK inhibitors, initially developed for haematology over 20 years ago, to be investigated for dermatological use. In this episode, Dr William (Bill) Damsky discusses JAK inhibitors’ journey from proof-of-concept to treating a wide range of skin conditions, their future impact on rare diseases and the debate around safety.
There is much excitement about the deployment of artificial intelligence (AI) in healthcare, and the musculoskeletal field is no exception. In this article, we introduce some of the latest developments relating to osteoarthritis (OA), osteoporosis, rheumatoid arthritis (RA) (as an ...
International experts from the American College of Rheumatology (ACR) and the European Alliance of Associations for Rheumatology (EULAR) have recently partnered to produce the much-anticipated classification criteria for antiphospholipid syndrome (APS), which were published in Arthritis & Rheumatology in August 2023.1 ...
Chronic back pain (CBP), defined as back pain lasting for 3 months or more, is the most common pain condition globally.1 Greater healthcare utilization, productivity limitations and poor quality of life have immediate and long-term impacts on patients and the healthcare ...
This corrects the article: “Gheriani GA, Tuetken R and Lenert P. Lane–Hamilton Syndrome: A Vasculitis Mimic Presenting with Diffuse Alveolar Haemorrhage and Positive ANCA Testing. touchREVIEWS in RMD. 2024;3(1):37–42” The patient consent statement was added incorrectly due to an editorial ...
It is increasingly recognized that autoimmune rheumatic diseases (ARDs) can affect people of any age, starting from early childhood and continuing until later in life. Furthermore, in recent decades, it has become apparent that Sjögren disease (SjD), commonly diagnosed ...
This editorial outlines a clinical approach to patients with periodic inflammation of unknown origin despite initial rational and targeted investigation. The focus of the editorial is on the recognition and diagnosis of systemic autoinflammatory diseases (SAIDs). Although rare, SAIDs are ...
The global burden of disease is heavily impacted by the increased prevalence of chronic inflammatory rheumatic diseases (CIRDs [rheumatoid arthritis (RA), spondyloarthritis (SpA), connective tissue diseases (CTDs) crystal arthropathies and polyarticular osteoarthritis (OA)]), which are prevalent chronic non-communicable diseases associated ...
Systemic lupus erythematosus (SLE) predominantly affects females and is characterized by multisystem involvement.1,2 Despite advancements in therapeutics, patients with SLE still experience poor health-related quality of life (HRQoL).3 Systemic sclerosis (SSc) is characterized by vasculopathy and fibrosis of the skin ...
Diffuse alveolar haemorrhage (DAH) is associated with high morbidity and mortality. The causes of DAH are diverse, and include rheumatologic conditions such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), Systemic lupus erythematosus (SLE) and Goodpasture’s syndrome (Table 1). Rheumatologists ...
Watch highlights of three ADVENT symposia presented at EADV 2023
Introducing the Editorial Board of touchREVIEWS in Immunology, who support our mission to advance medical knowledge and practice by ensuring the integrity, relevance, and impact of the content we publish. Together, we strive to foster a vibrant academic community and contribute to the continuous improvement of healthcare worldwide.
Rheumatoid Arthritis
Head of Clinical Sciences, Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
Peter C Taylor holds the Norman Collison chair of musculoskeletal sciences at the University of Oxford and is a Fellow of St. Peter’s College. He is Head of Clinical Sciences at the Botnar Research Centre within the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences. He studied pre-clinical medical sciences at Gonville and Caius College at the University of Cambridge and his first degree was in Physiology. He subsequently studied clinical medicine at the University of Oxford and was awarded a PhD degree from the University of London for research on pathogenesis of arthritis. Professor Taylor has specialist clinical interests in inflammatory arthritis. He has over 25 years’ experience in clinical trial design in studies of biologic and small molecular therapies in rheumatoid arthritis and ankylosing spondylitis. In experimental medicine studies, Professor Taylor employs targeted therapies as probes of pathogenesis to investigate the in vivo biology of the target in the pathobiology of the disease phenotype under investigation.
Rheumatoid Arthritis
Centre for Rheumatic Diseases, School of Immunology and Microbial Sciences, King’s College London, London, UK
Elena Nikiphorou, MBBS/BSc, FRCP, MD(Res), PGCME, FHEA Dr Elena Nikiphorou is a Consultant Rheumatologist and an Honorary Senior Lecturer at Kings College London. She completed her MBBS at University College London, also obtaining a first-class honours for her Intercalated BSc in physiology, a British Pharmacological Society Award and a Wellcome Trust Vacation Scholarship for her BSc Research. She has been the recipient of multiple awards, bursaries and competitive roles, including the Richard Kovacs prize by the Royal Society of Medicine in 2014, which supported a fellowship in Chicago and the Doris Hillier Award by the British Medical Association in 2018, to support her work on multimorbidity in rheumatoid arthritis and the development of management algorithms according to individual need. with a clinical/academic interest in inflammatory arthritis, rheumatoid arthritis and spondyloarthritis. She has expertise in all aspects of general rheumatology, including connective tissue and metabolic bone disease; crystal (e.g., gout) and reactive arthritis.
Rheumatoid Arthritis
Senior Rheumatologist at Cochin Hospital and Professor at the University of Paris, Rheumatology Department, Paris, France
Jérôme Avouac is a senior rheumatologist at Cochin Hospital and Professor at the University of Paris. He is responsible for a sector of day hospitalisation in the Rheumatology department, whose recruitment is mainly composed of patients with chronic inflammatory rheumatic disorders. He established a standardized systematic follow-up of joint involvement and systemic complications of rheumatoid arthritis and other inflammatory rheumatic diseases. Based on this standardized follow-up and clinical studies, he is developing medical approaches of personalized medicine for rheumatoid arthritis. Within the “Pathogenesis And Innovative Therapies In Chronic Fibro-Inflammatory Diseases” team at the Cochin Institute (INSERM U1016 UMR8104), Prof. Avouac leads innovative projects regarding the vascular aspects of inflammatory rheumatic disorders, especially rheumatoid arthritis. He also participates in the preclinical evaluation of anti-fibrotic treatments thanks to a platform of complementary animal models with dermal, pulmonary and vascular fibrosis.
Systemic Lupus Erythematosus
Rheumatologist, Division of Rheumatology, Northwell Health, and Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA
Dr Richard Furie is a rheumatologist whose activities for the last several decades have focused on patient care, physician education, and clinical research in the area of anti-rheumatic drug development. He directs The Program in Novel Therapeutics, the Health System’s clinical research program in musculoskeletal disease. He also directs the Hospital’s systemic lupus erythematosus (SLE) and Autoimmune Disease Treatment Center, which has become internationally recognized for its role in the development of new therapies for SLE. Regarded as one of the senior rheumatologists in the New York metropolitan area, he has served as a volunteer for the local chapters of the Arthritis Foundation and the Lupus Alliance, the Lupus Foundation of America, the SLE Foundation, the Lupus Research Alliance, and Lupus Therapeutics. He has served on many committees of the American College of Rheumatology and was named a Master of the College in 2018.
Explore the latest in medical education and stay current in your field. Create a free account to track your learning.
Earn and track your CME credits on the go, save articles for later, and follow the latest congress coverage.
Register for free to hear about the latest expert-led education, peer-reviewed articles, conference highlights, and innovative CME activities.
Or use a Social Account.
Explore the latest in medical education and stay current in your field. Create a free account to track your learning.