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Samantha Cooray, Alexander Deng, Tim Dong

There is much excitement about the deployment of artificial intelligence (AI) in healthcare, and the musculoskeletal field is no exception. In this article, we introduce some of the latest developments relating to osteoarthritis (OA), osteoporosis, rheumatoid arthritis (RA) (as an example of inflammatory arthritis), connective tissue disease (CTD), Ehlers–Danlos syndrome (EDS) and musculoskeletal surgical interventions. […]

Eamonn Quigley, DDW 2021: Biotherapeutic Blautia Hydrogentrophica in IBS

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Published Online: Jun 15th 2021

It was a pleasure to speak with Prof. Eamonn Quigley (Houston Methodist Hospital, Houston, TX, USA) about the phase 2 study of the single-strain live biotherapeutic, Blautia hydrogentrophica (Blautix), currently under investigation in irritable bowel syndrome (IBS).

His abstract entitled ‘A Phase 2 Study of Live Biotherapeutic Blautix in Irritable Bowel Syndrome (IBS) Patients with subtypes IBS-C and IBS-D’ (Sa607) was presented at DDW, 21-23 May 2021.

Questions

  1. What are the limitations of current treatments for IBS? (0:28)
  2. What is Blautix and what is the rationale for its use in the treatment of adults with IBS-C and IBS-D? (01:29)
  3. Could you tell us a little about the aims and design of the Phase II study you presented? (2:37)
  4. What are the efficacy and safety findings by region and what was the reason for the differences? (03:46)

Disclosures: Prof Eamonn Quigley has received research support, and acted as a consultant to 4D Pharma.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.

Filmed as a highlight of DDW 2021 (Virtual).

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