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The use of immune checkpoint inhibitors (ICIs) in treating cancer has greatly improved survival outcomes, particularly in patients with advanced disease for whom successful treatment options have previously been limited. For example, in patients with metastatic melanoma, the median survival time has improved from just 6 months to approximately 6 years with the use of […]

Xenofon Baraliakos, ACR 2022: Bimekizumab in the treatment of active non-radiographic axial spondyloarthritis and ankylosing spondylitis – 52 week findings from BE MOBILE 1 and 2

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Published Online: Nov 28th 2022

Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits both IL-17F and IL‑17A, was recently investigated in the phase 3 BE MOBILE 1 (NCT03928704) and BE MOBILE 2 (NCT03928743) clinical trials for active non-radiographic axial spondyloarthritis and ankylosing spondylitis, respectively. touchIMMUNOLOGY were delighted to speak with Dr. Xenofon Baraliakos (Ruhr-Universität Bochum, Bochum, Nordrhein-Westfalen, Germany) to discuss the rationale for the use of bimekizumab in these indications, and the efficacy and safety findings of the BE MOBILE 1 and 2 studies at 52 weeks.

This information is brought to you by Touch Medical Media and is not sponsored by, nor a part of, the American College of Rheumatology.

The abstract ‘Bimekizumab Maintains Improvements in Efficacy Endpoints and Has a Consistent Safety Profile Through 52 Weeks in Patients with Non-Radiographic Axial Spondyloarthritis and Ankylosing Spondylitis: Results from Two Parallel Phase 3 Studies.‘ (Abstract number: L14) was presented at the ACR Convergence, November 10–14, 2022.

Questions

  1. What is the rationale for the use of bimekizumab in the treatment of patients with active non-radiographic axial spondyloarthritis and ankylosing spondylitis? (0:26)
  2. Could you give us a brief overview of the BE MOBILE 1 and 2 studies and their primary findings? (2:10)
  3. What have been the efficacy and safety findings at 52 weeks? (3:20)
  4. If approved, what will be the clinical impact of bimekizumab in this indication? (6:34)

Disclosures: Xenofon Baraliakos discloses consulting for: Abbvie, Amgen, Chugai, Eli Lilly, Galapagos, Janssen, MSD, Novartis, Pfizer, Roche, Sandoz, and UCB; receiving grant/research support from: Abbvie, Lilly, and MSD; serving on advisory boards for: Abbvie, Amgen, Chugai, Eli Lilly, Galapagos, Janssen, MSD, Novartis, Pfizer, Roche, Sandoz, and UCB; receiving honoraria/honorarium from: Abbvie, Amgen, Chugai, Eli Lilly, Galapagos, Janssen, MSD, Novartis, Pfizer, Roche, Sandoz, and UCB; and participating in speaker’s bureaus with: Abbvie, Amgen, Chugai, Eli Lilly, Galapagos, Janssen, MSD, Novartis, Pfizer, Roche, Sandoz, and UCB.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.

Filmed in coverage of the ACR Convergence 2022.

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