Andrew Blauvelt, Dermatology Meeting News 2022: Malignancy Rates from a 5 Year Follow Up Study of the VOYAGE 1 and 2 Trials

touchIMMUNOLOGY were delighted to talk to Dr. Andrew Blauvelt (Oregon Medical Research Center, Portland, OR, USA) around the 5 year follow up study of the VOYAGE 1 and 2 trials, investigating guselkumab in patients with moderate to severe psoriasis.

The abstract ‘Malignancy Rates Through 5 Years of Follow-up in Guselkumab-treated Patients With Moderate to Severe Psoriasis: Results From the VOYAGE 1 and 2 Trials and Comparisons to General Populations’ was presented at AAD-VMX 2022, 25-29 March.

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Questions

1. What did the VOYAGE 1 and 2 clinical trials teach us about the efficacy and safety of guselkumab in the treatment of patients with moderate to severe psoriasis? (0:14)
2. What evidence has led to concern about possible associations between guselkumab treatment and malignancy risk? (2:06)
3. What have been the findings of the 5 year follow up of the VOYAGE 1 and 2 trials in terms of malignancy rates? (3:33)
4. What questions remain unanswered and what future studies are needed? (5:54)

Disclosures: Andrew Blauvelt has served as a speaker/received honoraria from AbbVie and UCB, served as a scientific adviser/received honoraria from AbbVie, Abcentra, Aligos, Almirall, Amgen, Anaptysbio, Arcutis, Arena, Aslan, Athenex, Boehringer Ingelheim, Bristol-Myers Squibb, Dermavant, EcoR1, Eli Lilly and Company, Evommune, Forte, Galderma, HighlightII Pharma, Incyte, Janssen, Landos, Leo, Merck, Novartis, Pfizer, Rapt, Regeneron, Sanofi Genzyme, Sun Pharma, UCB Pharma, Vibliome, and Xencor, and has acted as a clinical study investigator/institution has received clinical study funds from AbbVie, Amgen, Arcutis, Athenex, Boehringer Ingelheim, Bristol-Myers Squibb, Dermavant, Eli Lilly and Company, Galderma, Incyte, Janssen, Leo, Merck, Novartis, Pfizer, Regeneron, Sun Pharma, and UCB Pharma.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.

Filmed in coverage of the AAD-VMX annual meeting 2022.