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The use of immune checkpoint inhibitors (ICIs) in treating cancer has greatly improved survival outcomes, particularly in patients with advanced disease for whom successful treatment options have previously been limited. For example, in patients with metastatic melanoma, the median survival time has improved from just 6 months to approximately 6 years with the use of […]

Jonathan Bernstein, AAAAI 2021: Hereditary Angioedema – Prevalence, Pathogenesis, and Treatment Options

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Published Online: Mar 16th 2021

touchIMMUNOLOGY caught up with Jonathan Bernstein (University of Cincinnati; Bernstein Allergy Group, Bernstein Clinical Research Center, Cincinnati, OH, USA) to discuss the prevalence of hereditary angioedema, lanadelumab as a treatment option, and the current challenges faced by patients.

The abstract ‘Efficacy of Lanadelumab in Hereditary Angioedema Patients With and Without Prior Use of Long-Term Prophylaxis: Final Results From the HELP Open-Label Extension Study.’ (ABSTRACT NUMBER: 462) was presented at the American Academy of Allergy, Asthma & Immunology Virtual Annual Meeting, February 26-March 1, 2021.

Questions:

  1. Could you give us a brief overview of hereditary angioedema (HAE), its prevalence and pathogenesis? (0:20)
  2. Where does lanadelumab sit in the current treatment paradigm for the prevention of HAE attacks? (2:05)
  3. What are the challenges in individualised prescribing of lanadelumab for the prevention of HAE attacks? (3:50)

Disclosures: Jonathan Bernstein has nothing to disclose in relation to this video.

Support: Interview and filming supported by Touch Medical Media.

Filmed as a highlight of AAAAI 2021 (Virtual).

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