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The use of immune checkpoint inhibitors (ICIs) in treating cancer has greatly improved survival outcomes, particularly in patients with advanced disease for whom successful treatment options have previously been limited. For example, in patients with metastatic melanoma, the median survival time has improved from just 6 months to approximately 6 years with the use of […]

Marcus Maurer, EAACI 2021: Avapritinib for Advanced Systemic Mastocytosis – The PATHFINDER Study

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Published Online: Sep 3rd 2021

touchIMMUNOLOGY joins Professor Marcus Maurer (Charité – Universitätsmedizin Berlin, Berlin, Germany) at EAACI 2021 to discuss the rationale behind avapritinib for advanced systemic mastocytosis and the results of the PATHFINDER study.

Questions

  1. Could you give us a brief overview of the disease burden of advanced systemic mastocytosis and the unmet needs in its treatment? (0:26)
  2. What was the rationale for investigating avapritinib in the treatment of patients with advanced systemic mastocytosis? (1:04)
  3. Could you tell us a little about the PATHFINDER study and its findings? (1:39)
  4. How clinically meaningful are these benefits? (2:35)

Disclosures: In relation to this video interview, MM has received honoraria for advice as well as institutional research support by Blueprint and Celldex.

Support: Interview and filming supported by Touch Medical Media.

Filmed in coverage of the 2021 EAACI Annual Meeting.

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