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IgG4-RD is a rare, chronic, relapsing condition characterized by fibroinflammatory lesions rich in CD19+ B cells, which can damage multiple organ systems and lead to organ failure.1 With no approved therapies, glucocorticoids are the primary treatment, but their long-term use is associated with adverse effects and inadequate disease control.1
Research presented at the ACG 2024 Annual Scientific Meeting found no increased risk of major adverse cardiovascular events (MACE) or venous thromboembolism (VTE) in patients with inflammatory bowel disease (IBD) treated with Janus kinase inhibitors (JAKi) compared to those receiving anti-tumor necrosis factor (anti-TNF) therapy. This retrospective cohort study, led by Dr. Saqr Alsakarneh, analyzed data from 7,480 adult patients, showing comparable MACE and VTE rates across both treatment groups, even in older adults. These findings provide reassurance regarding the cardiovascular safety of JAKi in managing IBD, although further prospective studies are needed to validate long-term outcomes.
New research presented at UEG Week 2024 has introduced a strategy that could considerably reduce the need for insulin therapy in patients with type 2 diabetes (T2D).¹ The study investigated a novel approach combining ReCET (Re-Cellularization via Electroporation Therapy) with the ...
On September 23, 2024, the U.S. Food and Drug Administration (FDA) approved bimekizumab-bkzx (BIMZELX®, UCB) for the treatment of active psoriatic arthritis (PsA), active non-radiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation and active ankylosing spondylitis (AS).1 This makes bimekizumab-bkzx ...
Eosinophilic oesophagitis (EoE) is a chronic, immune-mediated inflammatory disease of the oesophagus that is progressive in nature and increasingly prevalent worldwide.1Â The condition is driven by antigen-induced type 2 inflammation, leading to the infiltration of eosinophils, which causes esophageal dysfunction and ...
A new study published in RMD Open has revealed that individuals with rheumatoid arthritis (RA) are significantly more likely to experience cognitive impairment. The study, which involved 70 RA patients and 70 matched healthy controls, showed that 60% of RA patients scored below the threshold for cognitive impairment on the Montreal Cognitive Assessment (MoCA), compared to 40% of the control group. This cognitive decline was most pronounced in visuospatial-executive function, memory and abstraction.
We are deeply saddened to learn that Prof. Marcus Maurer, a highly esteemed expert and valued member of the touchIMMUNOLOGY faculty, has been missing for several weeks following a hiking expedition in the mountains.
Managing hereditary angioedema effectively remains a significant challenge, but recent clinical trials presented at EAACI 2024, in Valencia, Spain, have shown promising advancements in treatment options.
The EASL 2024 meeting offered a great opportunity for hepatologists from around the world to discuss the latest data and tackle challenges in liver disease. Metabolic dysfunction-associated steatohepatitis (MASH) was a hot topic, with several exciting studies making waves. This article ...
As we have come to expect, EULAR 2024 was a busy and productive meeting, packed with news and lively discussions among rheumatologists. The conference, which took place in Vienna, Austria, highlighted a wealth of innovative research and significant advancements in rheumatology. ...
The European Alliance of Associations for Rheumatology (EULAR) proudly announces the launch of its 2024-2029 European Manifesto, addressing the urgent need for a coordinated response to rheumatic and musculoskeletal diseases (RMDs) across Europe.
Watch highlights of three ADVENT symposia presented at EADV 2023
Key updates from 2 cutting-edge expert symposia presented at WCD 2023
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