Atopic dermatitis is a chronic skin disorder, the prevalence of which is increasing. It is caused by interactions between the epidermal barrier and immune system, with activation of multiple T cell subsets, and characterised by pruritis and cutaneous inflammation. Topical treatments include topical corticosteroids, calcineurin inhibitors, emollients and cutaneous antiseptics; severe disease requires treatment in the form of systemic immunosuppressants. Increased understanding of the pathogenesis of atopic dermatitis has led to the development of targeted therapies, such as crisaborole, a topical phosphodiesterase 4 inhibitor, and dupilumab, a subcutaneously injected interleukin-4 receptor inhibitor. Emerging therapies include Janus kinase inhibitors, aryl hydrocarbon receptor agonists, antimicrobial peptides, and biologics targeting interleukin-13, the interleukin-31 receptor, and the interleukin-5 receptor.
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Atopic dermatitis is a chronic skin disorder causing inflammation, redness and irritation of the skin, and usually begins in childhood. touchIMMUNOLOGY caught up with Prof Amy Paller (Northwestern University Feinberg School of Medicine; Lurie Children's Hospital of Chicago, Chicago, IL, ...
JADE-EXTEND (NCT03422822) is a phase 3 long-term extension study investigating the efficacy and safety of abrocitinib in atopic dermatitis. In this touchIMMUNOLOGY interview, we caught up with Dr. Melinda Gooderham (SKiN Centre for Dermatology, Ontario, Canada) around her interim analysis of ...
There are numerous therapeutics available to patients with inflammatory skin diseases, including TNF-alpha inhibitors, IL inhibitors, TYK2 and JAK inhibitors, optimising the use of these therapies could be achieved with a personalised approach to treatment. We were delighted to speak ...
ADvocate 1 (NCT04146363) and ADvocate 2 (NCT04178967) are phase 3, randomised, double-blind, placebo-controlled trials, investigating lebrikizumab monotherapy in moderate to severe atopic dermatitis. touchIMMUNOLOGY caught up with Prof. Gil Yosipovitch (Miller School of Medicine, University of Miami, Miami, FL, USA) around the ADvocate 1 and ADvocate 2 phase 3 studies and the findings from his analysis of these studies presented at EADV, focusing on improvement in itch severity. The abstract 'Lebrikizumab monotherapy improved itch in adults and adolescents with moderate to severe atopic dermatitis in two phase 3 trials.' (Abstract number: 765) was presented at EADV 2022, 7-10 September, 2022. Questions What is the impact of itch on quality of life in atopic dermatitis? (0:21) Could you give us a brief overview of the ADvocate 1 and ADvocate 2 studies and their primary findings? (0:38) What were the findings in terms of itch severity, and how clinically meaningful was this change? (1:26) What will be the clinical impact of these findings? (2:51) Disclosures: Gil Yosipovitch discloses consulting for Sanofi Regeneron, Eli Lilly, Galderma, Sanofi, Kiniksa, Trevi, Escient and Pfizer; receiving grant/ research support from Sanofi Regenron, Eli Lilly, Novartis, Pfizer, Escient; serving on advisory boards for Sanofi Regeneron, Eli Lilly, Galderma, Sanofi, Kiniksa, Trevi, Escient and Pfizer; receiving honoraria from Sanofi Regeneron, Eli Lilly, Galderma, Sanofi, Kiniksa, Trevi, Escient, Pfizer and Novartis. Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones. This content was developed by Touch Medical Media and is not affiliated with the  European Academy of Dermatology & Venereology  (EADV) or the congress.Â
Paediatric atopic dermatitis is a common chronic skin condition in children that results in dry, itchy skin. It was a pleasure to talk with Dr. Laura Carucci (University of Naples Federico II. Naples, Italy) to discuss the aims, outcome measures ...
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