Digestive Disorders
An Introduction to Digestive Disorders
Inflammatory bowel disease is a term used to describe chronic, relapsing inflammatory disorders of the digestive tract. The major types are ulcerative colitis, which causes inflammation in the colon, and Crohn’s disease, which may affect any part of the digestive tract, from mouth to anus. Symptoms include abdominal pain, blood in the stool, irregular bowel habits, weight loss and fatigue. Established treatment options are surgery, aminosalicylates, corticosteroids, immunomodulators and anti-TNFα inhibitors; however, many patients will fail to respond or become refractory to these therapies. Emerging therapies include anti-integrin therapy, JAK1 inhibitors, sphingosine-1-phosphate receptor modulators, stem-cell transplant and faecal microbiota transplant.
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Prof. Paul Fockens, recipient of the 2024 UEG Lifetime Achievement Award, has profoundly shaped the field of gastrointestinal endoscopy. From pioneering techniques like endoscopic ultrasound to advancing colorectal cancer screening and minimally invasive surgeries, his transformative contributions have improved patient care globally. A dedicated mentor and leader, Prof. Fockens has also championed education and innovation through his work with UEG and beyond."
Each year, the United European Gastroenterology (UEG) organisation awards a prestigious €50,000 Research Prize to recognise excellence in basic science, translational, or clinical research. This award supports future innovative scientific projects from inception to completion, emphasizing their transformative potential to enhance patient care. This year’s recipient, Dr. Enrique de-Madaria, Gastroenterologist and Coordinator of the Biliary-Pancreatic Unit at Dr. Balmis Hospital in Alicante, Spain, has been honoured for his groundbreaking work in fluid resuscitation for acute pancreatitis. Over the past decade, his multicentre studies—bolstered by national and international collaborations—have redefined clinical practice and established new standards of care.
IgG4-RD is a rare, chronic, relapsing condition characterized by fibroinflammatory lesions rich in CD19+ B cells, which can damage multiple organ systems and lead to organ failure.1 With no approved therapies, glucocorticoids are the primary treatment, but their long-term use is associated with adverse effects and inadequate disease control.1
New research presented at UEG Week 2024 has introduced a strategy that could considerably reduce the need for insulin therapy in patients with type 2 diabetes (T2D).¹ The study investigated a novel approach combining ReCET (Re-Cellularization via Electroporation Therapy) with the ...
Eosinophilic oesophagitis (EoE) is a chronic, immune-mediated inflammatory disease of the oesophagus that is progressive in nature and increasingly prevalent worldwide.1Â The condition is driven by antigen-induced type 2 inflammation, leading to the infiltration of eosinophils, which causes esophageal dysfunction and ...
Three experts discuss the challenges related to recognizing, diagnosing and treating patients with eosinophilic oesophagitis (EoE) and highlight how advances in diagnostic tools and emerging treatments may impact future care.
The UEG Young Talent Group (YTG) encourages young gastroenterologists to develop their careers through education, networking and training. We were delighted to catch up with UEG YTG Chair Dr. Pilar Acedo to discuss the training, education and professional opportunities available ...
Digestive Disease Week took place between 6-9 May, in this touchIMMUNOLOGY interview, we caught up with our Expert Faculty member Prof. Gil Y. Melmed (Cedars-Sinai, Los Angeles, CA, USA) around his personal highlights from this year’s conference including non-pivotal ...
Upadacitinib and tofacitinib are both JAK inhibitors (JAKis) approved by the FDA for the treatment of ulcerative colitis. In this interview with Expert Faculty member Prof. Gil Y. Melmed (Cedars-Sinai, Los Angeles, CA, USA) we discuss the aims, design and ...
The phase 3 LIBERTY-EoE-TREET study (NCT03633617) investigated the efficacy and safety of dupilumab in eosinophilic esophagitis. In this interview we spoke with Dr. Margaret Collins (Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA) around her analysis of the phase 3 study ...
Dupilumab, a fully human monoclonal antibody that works by blocking IL-4Rα, is currently approved for the treatment of eosinophilic esophagitis (EoE) in the USA and EU. It was a pleasure to talk with Dr. Margaret Collins (Cincinnati Children’s ...
The phase 3 LIBERTY-EoE-TREET study (NCT03633617) evaluated the efficacy and safety of dupilumab in adult and adolescent patients with eosinophilic oesophagitis. We caught up with Prof Arjan Bredenoord (Amsterdam University Medical Center, Amsterdam, the Netherlands) to discuss the part C subgroup ...
Dupilumab is a fully human monoclonal antibody that inhibits the interleukin-4 and interleukin-13 pathways, and has been approved for the treatment of eosinophilic oesophagitis in the USA and Europe. touchIMMUNOLOGY caught up with Prof Arjan Bredenoord (Amsterdam University Medical Center, ...
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