A globally recognized allergologist specializing in urticaria, drug allergies, and angioedema, Professor Luis FC Ensina has significantly advanced clinical care, research, and education. As a Professor at the Federal University of São Paulo and coordinator of its specialized outpatient clinic, he leads Alergoalpha, a Center of Excellence for UCARE, ACARE, and ADCARE, where he has overseen over 20 clinical trials and authored more than 100 publications. A founder of the Brazilian Urticaria Network (RUBRA) and co-author of international urticaria guidelines, he has played a pivotal role in shaping global standards for allergy care. Active in organizations such as GA2LEN, AAAAI, and EAACI, he highlights the transformative potential of emerging therapies, gene therapy, and artificial intelligence to redefine allergy and immunology practice worldwide.