Axial Spondyloarthritis
An Introduction to Axial Spondyloarthritis
Axial spondyloarthritis (axSpA) is an inflammatory disease of the axial skeleton, and causes significant back pain and disability. Treatment involves non-steroidal anti-inflammatory drugs (NSAIDs), physical therapy and exercise. Several anti-tumour necrosis factor (TNF) agents are approved for treatment of radiographic axSpA. Emerging therapeutic targets include interleukin (IL) -17 and the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. Other emerging treatments include compounds that target IL-17A and IL-17F isoforms and granulocyte macrophage-colony stimulating factor (GM-CSF). However, many unmet needs remain, including optimising treatment response and biomarkers to identify patients with chronic back pain who may progress to axSpA.
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On September 23, 2024, the U.S. Food and Drug Administration (FDA) approved bimekizumab-bkzx (BIMZELX®, UCB) for the treatment of active psoriatic arthritis (PsA), active non-radiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation and active ankylosing spondylitis (AS).1 This makes bimekizumab-bkzx ...
Spondyloarthritides are chronic rheumatic diseases associated with diverse extra-articular manifestations, such as psoriasis, uveitis and inflammatory bowel diseases (IBDs), namely Crohn’s disease (CD) and ulcerative colitis (UC). Historically, spondyloarthritis (SpA) was divided into several subcategories, namely, ankylosing spondylitis (AS), ...
The term spondyloarthritis (SpA) encompasses a number of disease entities that share common clinical, biological and genetic characteristics. Common clinical features include inflammation in the axial skeleton, including the spine and sacroiliac joints, and inflammation of peripheral musculoskeletal structures such ...
The seronegative spondyloarthritides are a group of inflammatory arthropathies that are related in aspects of their clinical and radiographic presentations and genetic predisposition. Psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA) are two of the major diseases classified under this umbrella, ...
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