Respiratory Disorders
An Introduction to Respiratory Disorders
Asthma is a chronic inflammatory disorder of the airwaves and one of the most common respiratory diseases. While the majority of cases can be controlled, severe asthma is associated with high risk of exacerbations and death. Severe asthma is categorised as T-helper type 2 (T2) high and T2 low. T2 high, also known as eosinophilic asthma, involves generation of cytokines including interleukin-4, −5 and −13. Recently, the management of severe eosinophilic asthma has been transformed by the development of monoclonal antibodies. Other allergic respiratory diseases include allergic rhinitis, which can be managed via symptomatic treatment with antihistamines, and allergy immunotherapy.
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