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The use of immune checkpoint inhibitors (ICIs) in treating cancer has greatly improved survival outcomes, particularly in patients with advanced disease for whom successful treatment options have previously been limited. For example, in patients with metastatic melanoma, the median survival time has improved from just 6 months to approximately 6 years with the use of […]

Kathryn Torok, ACR 2021: Autologous Stem Cell Transplant in Treatment-Resistant Juvenile-onset Systemic Sclerosis

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Published Online: Nov 11th 2021

In this interview, we talk with Professor Kathryn Torok (UPMC & University of Pittsburgh Scleroderma Center, University of Pittsburgh, Pittsburgh, PA, USA) around CD34-selected peripheral blood ASCT in patients with juvenile-onset systemic sclerosis (NCT03630211).

This information is brought to you by Touch Medical Media and is not sponsored by, nor a part of, the American College of Rheumatology.

The abstract ‘Autologous Stem Cell Transplantation with CD34-Selected Peripheral Blood Stem Cells in Patients with Treatment-Resistant Juvenile-Onset Systemic Sclerosis.’ (ABSTRACT NUMBER: 0778) was presented at the ACR Convergence 2021, 3-9 November 2021.

Questions

  1. What is known about the clinical utility of autologous stem cell transplant (ASCT) in patients with aggressive and recalcitrant juvenile-onset systemic sclerosis? (0:16)
  2. Could you tell us a little about the reduced intensity conditioning protocols you have developed using CD34-selected peripheral blood ASCT? (2:48)

Disclosures: Kathryn Torok has nothing to disclose in relation to this video.

Correspondence: Kathryn Torok, MD, Associate Professor of Pediatrics, Division of Pediatric Rheumatology, UPMC & University of Pittsburgh Scleroderma Center, University of Pittsburgh |UPMC Children’s Hospital of Pittsburgh, 4401 Penn Ave, Pittsburgh, PA 15224, Tel: (412) 692-5081 | Fax: (412) 692-5054 | kathryn.torok@chp.edu

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.

Filmed in coverage of the virtual ACR Convergence 2021.

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