We were delighted to speak with Dr. Michaela Koehm (Goethe University, Frankfurt am Main, Germany) to discuss her trial investigating the effect of methotrexate on ustekinumab treatment for active psoriatic arthritis.
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The abstract ‘Neither Add-on nor Withdrawal of Methotrexate Impacts Efficacy of IL12/23 Inhibition in Active PsA: Data from a Multicenter Investigator-initiated Randomized Placebo-controlled Clinical Trial on Arthritis, Dactylitis, Enthesitis, Psoriasis, QoL and Function.’ (ABSTRACT NUMBER: L12) was presented at the ACR Convergence, 5-9 November 2021.
- What is the rationale for combining methotrexate with a biological disease-modifying antirheumatic drug (DMARD) in the treatment of active psoriatic arthritis (PsA)? (0:20)
- What were the aims and design of the clinical trial you are presenting? (1:01)
- What were the efficacy and safety findings of the study? (1:40)
- Why do you think methotrexate had no effect on the efficacy of ustekinumab? (2:15)
- What questions remain unanswered and what future studies are planned? (4:04)
Disclosures: Michaela Koehm discloses receiving a research grant from Janssen.
Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.
Filmed in coverage of the virtual ACR Convergence 2021.
